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. 2016 May 3;5(5):e003474. doi: 10.1161/JAHA.116.003474

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Effects of LepA application at the surface of the ascending aorta on AngII‐induced thoracic aortic aneurysm formation and left ventricular remodeling. A radar plot of quantitative cardiovascular parameters assessed in this study demonstrating the impact of LepA applied on the surface of the ascending aorta in AngII‐infused mice. The distance from center is measured by a Z score calculated from the standard deviation in mice treated with an empty polylactic co–glycolic acid film (black, control). Red line corresponds to the AngII‐infused mice alone, whereas the green line corresponds to the AngII and LepA‐treated mice. Moving clockwise, LepA application attenuates the effects of AngII on ascending aortic diameter, hemodynamics at the LV outlet, LV wall thickness, FAC, and LV valves’ leaflets thickness. There is no effect on blood pressure or weight gain. AngII indicates angiotensin II; FAC, fractional area change; LepA, leptin antagonist; LV, left ventricular; PSV, peak systolic velocity.