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. Author manuscript; available in PMC: 2017 May 19.
Published in final edited form as: Cell. 2016 Apr 28;165(5):1209–1223. doi: 10.1016/j.cell.2016.04.012

Figure 1. Lifespan Extension by Mitochondrial ETC Perturbation Requires the Histone Demethylases jmjd-1.2 and jmjd-3.1.

Figure 1

(A) and (B) Knockdown of jmjd-1.2 (A) or jmjd-3.1 (B) suppresses cco-1-mediated lifespan extension.

(C) jmjd-1.2 is partially required for longevity of isp-1(qm150) mutant animals.

(D) jmjd-3.1 is required for longevity of isp-1(qm150) mutant animals.

(E) and (F) Dietary restriction-mediated longevity of eat-2(ad1116) animals is not affected by jmjd-1.2 (E) or jmjd-3.1 (F) knockdown.

(G) Longevity of daf-2(e1370) mutant animals is not affected by jmjd-1.2 knockdown.

(H) Longevity of daf-2(e1370) mutant animals partially depends on jmjd-3.1. See also Figure S1 and Table S1 for lifespan statistics.