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Cell cycle progression in verterbrate cells after UV-C damage. A schematic model showing the possible outcomes as a cell progresses through the cell cycle after UV-C damage, in comparison with undamaged cells. Work described here has identified differences in the percentage of cells achieving each outcome, dependent on its complement of TLS polymerases. An increase in Outcome 4 is observed in the absence of PrimPol, while Outcome 3 becomes more prevalent in cells lacking Pol η.
