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Bidirectional crosstalk between HSC and their microenvironment. HSC and Myeloid Progenitors (MP) are found in perivascular structures and are regulated by cytokines such as CXCL12 or TGF-β secreted by niche cells, including NestinHI mesenchymal stem cells (NesHI MSC), CXCL12-abundant reticular (CAR) cells and megakaryocytes (MK). HSC and MP can reciprocally regulate neighboring progenitors and stromal niche cells through TGF-β.
