Figure 2.

NEK2 interacting signaling. The figure is a schematic diagram depicting the interaction of NEK2 and its related proteins. This view represents frequently studied aspects of NEK2 activities along with several newly described interactions. Aberrant activation of NEK2 by its upstream proteins or overexpression of NEK2 results in the activation of its downstream proteins, not only leading to the malfunction of NEK2 in normal cell cycle regulation, but also interrupting apoptosis, metastasis and drug resistance.