Figure 1.

The Role of DNA Double Strand Break and the NHEJ Signaling Pathway in Transcription of Inducible Genes. We depict recruitment to gene promoters, by a transcription factor dimer, of a complex containing NHEJ proteins including DNA-PK, as well as Topoisomerase IIβ and PARP1. Following generation of a DSB in the promoter by Topoisomerase IIβ, DNA repair pathways are triggered, resulting in the activation of DNA-PK that phosphorylates substrates such as H2AX and Kap1/TRIM28 throughout the transcribing gene, permitting RNA elongation by Pol II.