Table 3.
The most relevant functional networks and biological processes present in the gene lists.
| Low Gleason vs. high Gleason | |
|---|---|
| Top networks | Score |
| Embryonic Development, Nervous System Development and Function, organ Development | 50 |
| Skeletal and Muscular System Development and Function, Connective Tissue Development and Function, Embryonic Development | 35 |
| Cellular Development, Gene Expression, Embryonic Development | 33 |
| Organismal Injury and Abnormalities, Skeletal and Muscular Disorders, Neurological Disease | 33 |
| Cellular Development, Nervous System Development and Function, Visual System Development and Function | 29 |
| Top bio functions related to diseases and disorders | P-value |
| Developmental Disorder | 5.11E-09 – 6.14E-04 |
| Gastrointestinal Disease | 5.11E-09 – 6.14E-04 |
| Neurological Disease | 4.09E-08 – 6.32E-04 |
| Psychological Disorders | 4.09E-08 – 4.47E-04 |
| Skeletal and Muscular Disorders | 1.39E-07 – 6.14E-04 |
| Top canonical pathways | P-value |
| Basal Cell Carcinoma Signaling | 5.57E-05 |
| Corticotropin Releasing Hormone Signaling | 9.83E-05 |
| Neuropathic Pain Signaling In Dorsal Horn Neurons | 8.48E-04 |
| nNOS Signaling in Neurons | 1.02E-03 |
| Factors Promoting Cardiogenesis in Vertebrates | 1.42E-03 |
| Normal vs. Cancer | |
| Top networks | Score |
| RNA Post-Transcriptional Modification, Cell Cycle, Cellular Assembly and Organization | 40 |
| Nervous System Development and Function, Tissue Development, Tissue Morphology | 38 |
| Gene Expression, Cellular Development, Connective Tissue Development and Function | 38 |
| Cell Signaling, Carbohydrate Metabolism, Molecular Transport | 38 |
| Embryonic Development, Organismal Development, Skeletal and Muscular System Development and Function | 36 |
| Top bio functions related to diseases and disorders | P-value |
| Developmental Disorder | 6.69E-18 – 3.69E-05 |
| Skeletal and Muscular Disorders | 3.60E-15 – 4.46E-05 |
| Cancer | 6.67E-15 – 4.25E-05 |
| Gastrointestinal Disease | 9.35E-14 – 1.69E-05 |
| Neurological Disease | 5.51E-11 – 4.46E-05 |
| Top canonical pathways | P-value |
| EIF2 Signaling | 1.16E-09 |
| Transcriptional Regulatory Network in Embryonic Stem Cells | 3.13E-08 |
| Wnt/b-catenin Signaling | 1.54E-05 |
| Regulation of eIF4 and p70S6K Signaling | 3.66E-05 |
| Axonal Guidance Signaling | 9.69E-05 |