Table 2.
Ether-linked PC and ether-linked PE species changed to a statistically significant extent 24 h post-IR-induced AKI
| Lipid | MS/MS, m/z | Intensity Change | Fold-Change | Lipid | MS/MS, m/z | Intensity Change | Fold-Change |
|---|---|---|---|---|---|---|---|
| PC O-20:5 | 542.4_184.1 | 75.7→ND | − | PC O-46:2 | 912.8_184.1 | 1296.8→2044.6 | +1.6 |
| PC O-20:6 | 540.4_184.1 | 72.8→ND | − | PC O-48:0 | 944.8_184.1 | 1059.4→1867.8 | +1.8 |
| PC O-30:4 | 684.5_184.1 | ND→175.1 | + | PC O-48:1 | 942.8_184.1 | 1224.9→2333.8 | +1.9 |
| PC O-32:1 | 718.6_184.1 | 815.4→3278.8 | +4.0 | PC O-48:2 | 940.8_184.1 | 1777.2→3636.6 | +2.1 |
| PC O-32:6 | 708.5_184.1 | 32.7→2.9 | −11.3 | PC O-48:3 | 938.8_184.1 | 1707.0→3629.3 | +2.1 |
| PC O-34:3 | 742.6_184.1 | 117.8→30.1 | −3.9 | PE O-26:3 | 588.4_198.1 | 38.1→1.8 | −21.2 |
| PC O-34:4 | 740.6_184.1 | 70.0→24.6 | −2.9 | PE O-34:0 | 706.5_198.1 | 81.4→ND | |
| PC O-36:0 | 776.6_184.1 | 227.4→520.6 | +2.3 | PE O-34:1 | 718.6_198.1 | 62.3→1.8 | −34.6 |
| PC O-36:1 | 774.6_184.1 | 263.2→950.9 | +3.6 | PE O-36:0 | 734.6_198.1 | 1080.5→9.5 | −113.7 |
| PC O-36:3 | 770.6_184.1 | 1583.1→757.4 | −2.1 | PE O-36:1 | 732.6_198.1 | 130.9→2.9 | −45.1 |
| PC O-36:4 | 768.7_184.1 | 2618.3→1422.4 | −1.8 | PE O-36:6 | 722.6_198.1 | 26.3→ND | − |
| PC O-36:5 | 766.6_184.1 | 810.3→469.7 | −1.7 | PE O-38:1 | 760.6_198.1 | 85.6→ND | − |
| PC O-38:0 | 804.7_184.1 | 708.9→1266.8 | +1.8 | PE O-38:5 | 752.6_198.1 | 78.1→2.1 | −37.2 |
| PC O-38:1 | 802.7_184.1 | 1068.9→1915.5 | +1.8 | PE O-40:0 | 790.7_198.1 | 55.0→ND | |
| PC O-38:2 | 800.7_184.1 | 1044.7→1614.4 | +1.6 | PE O-40:1 | 788.7_198.1 | 127.6→2.0 | −63.8 |
| PC O-38:4 | 796.7_184.1 | 985.0→1548.1 | +1.6 | PE O-40:2 | 786.6_198.1 | 226.5→1.4 | −161.8 |
| PC O-38:5 | 794.7_184.1 | 739.6→1470.4 | +2.0 | PE O-40:3 | 784.6_198.1 | 418.8→2.3 | −182.1 |
| PC O-38:6 | 792.7_184.1 | 583.5→1064.1 | +1.8 | PE O-40:4 | 782.6_641.6 | 0.83→ND | − |
| PC O-40:5 | 822.7_184.1 | 927.1→2110.9 | +2.3 | PE O-40:6 | 778.6_198.1 | 145.4→0.4 | −363.5 |
| PC O-42:0 | 860.7_184.1 | 3957.8→6326.0 | +1.6 | PE O-42:0 | 818.7_198.1 | 198.3→7.1 | −28.0 |
| PC O-44:0 | 888.7_184.1 | 3229.0→5976.6 | +1.9 | PE O-42:1 | 816.7_198.1 | 296.8→2.5 | −118.7 |
| PC O-44:1 | 886.7_184.1 | 1066.5→2880.9 | +2.7 | PE O-42:2 | 814.6_198.1 | 257.7→3.5 | −73.6 |
| PC O-46:1 | 914.8_184.1 | 1093.2→2015.6 | +1.8 | PE O-42:3 | 812.6_198.1 | 516.3→7.4 | −69.8 |
| PE O-42:4 | 810.7_198.1 | 244.1→1.4 | −174.4 | PE O-46:2 | 870.7_198.1 | 582.6→17.7 | −32.9 |
| PE O-42:5 | 808.7_198.1 | 80.3→8.9 | −9.0 | PE O-46:3 | 868.8_198.1 | 817.7→21.2 | −38.6 |
| PE O-42:6 | 806.7_198.1 | 76.1→9.0 | −8.5 | PE O-46:4 | 866.7_198.1 | 611.1→14.8 | −41.3 |
| PE O-44:0 | 848.7_198.1 | 201.1→7.2 | −2.8 | PE O-46:5 | 864.7_198.1 | 188.5→3.6 | −52.4 |
| PE O-44:1 | 844.7_198.1 | 1167.3→24.1 | −48.4 | PE O-46:6 | 862.7_198.1 | 274.7→9.4 | −29.2 |
| PE O-44:2 | 842.7_198.1 | 1165.8→29.1 | −40.1 | PE O-48:0 | 902.8_198.1 | 789.7→30.8 | −25.6 |
| PE O-44:3 | 840.7_198.1 | 2050.0→44.5 | −46.1 | PE O-48:1 | 900.7_198.1 | 302.9→10.7 | −28.3 |
| PE O-44:4 | 838.7_198.1 | 1047.9→25.7 | −40.1 | PE O-48:2 | 898.8_198.1 | 392.0→12.2 | −32.1 |
| PE O-44:6 | 834.7_198.1 | 223.5→8.5 | −26.3 | PE O-48:4 | 894.7_198.1 | 1061.0→19.3 | −55.0 |
| PE O-46:0 | 874.7_198.1 | 985.7→33.4 | −29.5 | PE O-48:5 | 892.8_198.1 | 973.8→27.9 | −34.9 |
| PE O-46:1 | 872.7_198.1 | 589.5→16.1 | −36.6 | PE O-48:6 | 890.7_198.1 | 1066.1→37.4 | −28.5 |
ND: not detected. Phospholipids that were increased at 6 h post-IR are in italics. Reductions are highlighted in bold. Note that all statistically significant changes in ether-linked PEs 24 h post-IR were reductions.