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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Pediatr Dent. 2012 Sep-Oct;34(5):120–128.

Table 1.

CLINICAL STUDIES OF MINERAL TRIOXIDE AGGREGATE PRIMARY TOOTH PULPOTOMY*

Study Sample
size		 Inclusion
criteria		 Recall
(mos)		 Pulpotomy
technique		 Sample size
(end of study)		 Clinical success
(%)		 Radiographic
success (%)
Doyle et al.34 FS: 58
EF-FS: 78
GMTA: 57
FS/GMTA: 77		 Symptomless,
deep caries and
vital pulp		 6-38

  1. FS

  2. FS followed by eugenol-free filling material

  3. GMTA

  4. FS followed by GMTA

 FS: 46
EF-FS: 64
GMTA: 47
FS/GMTA: 70		 FS: 78
EF-FS: 74
GMTA: 100
FS/GMTA: 90		 FS: 74
 IRR: 33
 PCO: 28
EF-FS: 52
 IRR: 31
 PCO: 13
GMTA: 96
 IRR: 6
 PCO: 43
FS/GMTA: 87
 IRR: 17
 PCO: 34
Subramaniam
et al.20 		DFC: 20
GMTA: 20		 Symptomless,
carious exposure
of vital pulp		 24 DFC 1 min vs GMTA
2-stage restoration
with SSC within
1 week		 DFC: 20
GMTA: 20		 DFC: 100
GMTA: 100		 DFC: 85
GMTA: 95
 PCO: 25
Sakai et al.35 PC: 15
GMTA: 15		 Symptomless,
carious molar
with vital pulp		 24 PC vs GMTA
All restored with GI		 PC: 9
GMTA: 9		 PC: 100
GMTA: 100		 PC: 100
GMTA: 100
Sonmez36 DFC: 20
FS: 20
CH: 20
GMTA: 20		 Carious exposure
of vital pulp		 6-24

  1. DFC 5 min

  2. FS

  3. CH

  4. GMTA

 DFC: 13
FS: 15
CH: 13
GMTA: 15		 DFC: 85
FS: 100
CH: 92
GMTA: 93		 DFC: 77
FS: 73
CH: 46
GMTA: 67
Noorollahian21 DFC: 30
GMTA: 30		 Carious exposure
of vital pulp		 6-24 DFC 5 min vs GMTA
2-stage restoration
with SSC after 24 hrs		 DFC: 27
GMTA: 29		 DFC: 100
GMTA: 100		 DFC: 100
 PCO: −22
GMTA: 95
 PCO: −5
Moretti et al.22 CH: 15
DFC: 15
GMTA: 15		 Carious exposure
of vital pulp		 3-24 DFC 5 min vs CH
vs GMTA
All restored with GI		 CH: 14
DFC: 15
GMTA: 14		 CH: 57
DFC: 100
GMTA: 100		 CH: 36
 IR: 43
DFC: 100
GMTA: 100
 DB: 29
Aeinehchi et al.37 FC: 75
GMTA: 51		 Deep caries 3-6 FC 5 min vs GMTA FC: 57
GMTA: 43		 FC: 100
GMTA: 100		 FC: 89
 IR: 11
GMTA: 100
Maroto et al.38 GMTA: 69 Carious exposure
of vital pulp		 42 GMTA 26 (11 teeth
exfoliated by
42 months)		 GMTA: 100 GMTA: 99
 PCO: 84
 DB: 83
Percinoto et al.39 CH: 45
GMTA: 45		 Carious exposure
of vital pulp		 12 CH vs GMTA CH: 45
GMTA: 45		 CH: 87
GMTA: 96
Holan et al.4 FC: 29
MTA: 33		 Symptomless,
carious exposure
of vital pulp		 4-74 Full-strength FC
(5 min) vs MTA		 FC: 24
MTA: 32		 FC: 83
MTA: 97
(combined
success)		 FC:
 IRR: 21
 PCO: 52
MTA:
 IRR: 6
 PCO: 58
Saltzman et al.32 FC-ZOE: 26
L-GMTA: 26		 Carious exposure
of vital pulp		 3- 15 Full-strength FC
(5 min) + ZOE base vs
Diode laser + GMTA		 FC-ZOE: 13
L-GMTA: 7		 FC-ZOE: 100
L-GMTA: 100		 FC-ZOE: 89
L-MTA: 73
Maroto et al.40 GMTA: 20 Carious exposure
of vital pulp		 6 GMTA GMTA: 20 GMTA: 100 GMTA: 100
 DB: 55
 PCO: 60
Naik et al.23 DFC: 23
GMTA: 24		 Carious exposure
of vital pulp		 6 DFC (5 min) vs
GMTA		 DFC: 23
GMTA: 24		 DFC: 100
GMTA: 100		 DFC: 100
GMTA: 100
Farsi et al.41 FC: 60
GMTA: 60		 Carious exposure
of vital pulp		 6-24 Full-strength FC
(5 min) vs GMTA		 FC: 35
MTA: 38		 FC: 97
GMTA: 100		 FC: 86
 IRR: 14
 PCO: 3
GMTA: 100
 PCO: 8
Jabbarifar et al.42 FC: 32
GMTA: 32		 Symptomless,
carious exposure
of vital pulp		 6-12 Full-strength FC
(5 min) vs GMTA		 FC: 29
GMTA: 30		 FC: 91
GMTA: 94		 FC: 91
 IRR: 9
GMTA: 94
 IRR: 6
Agamy et al.43 FC: 24
WMTA: 24
GMTA: 24		 Carious exposure
of vital pulp		 1-12 Full-strength FC
(5 min) vs GMTA		 FC: 20
WMTA: 19
GMTA: 19		 FC: 90
WMTA: 80
GMTA: 100		 FC: 90
WMTA: 80
GMTA: 100
 PCO: 56
Cuisia et al.44 FC: 30
GMTA: 30		 Carious exposure
of vital pulp		 6 Full-strength FC
(5 min) vs GMTA		 FC: 30
GMTA: 30		 FC: 93
GMTA: 97		 FC: 77
MTA: 93
Eidelman et al.45 FC: 22
GMTA: 23		 Carious exposure
of vital pulp		 6-30 Full-strength FC
(5 min) vs GMTA		 FC: 15
GMTA: 19		 FC: 93
GMTA: 100		 FC: 93
 IRR: 7
 PCO: 13
GMTA: 100
 PCO: 41
*

FC=formocresol.

CH=calcium hydroxide.

EF-FS=eugenol-free ferric sulfate.

IPT=indirect pulp therapy.

PCO=pulp canal obliteration.

PC=Portland cement.

FR=furcation radiolucency.

ZOE=zinc oxide eugenol.

FR=furcation radiolucency.

GMTA=gray mineral trioxide aggregate.

WMTA=white mineral trioxide aggregate.

ER=external root resorption.

DB=dentin bridge formation.

SSC=stainless steel crown.

IRR=internal root resorption.

CM=calcific metamorphosis.

PR=periapical radiolucency.

IR=internal.

FS=ferric sulfate.

AM=amalgam.

GI=glass ionomer.