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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Small. 2016 Mar 31;12(19):2616–2626. doi: 10.1002/smll.201503342

Figure 4.

Figure 4

Analysis of DNA damage in response to drug exposure in the device. (A) Immunostaining of γ-H2AX and DAPI in the microfluidic device under conditions of FUS-exposure, no-drug release (0.3μM doxorubicin-TS-liposomes) and FUS-triggered drug release (FUS & drug: 0.3μM). Each image corresponds to a single confocal slice. Scale bar corresponds to 100μm. (B) Quantification of staining intensity per cell in (A). Average values (n=40), and error bars represent standard deviation. Values normalized to the γ-H2AX intensity for the FUS only condition. Statistically significant differences are highlighted (*** p<0.001).