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. 2016 May 9;113(21):5940–5945. doi: 10.1073/pnas.1520302113

Fig. 5.

Fig. 5.

Effect of cysteine cross-linking on macrofibril morphology and follicle mechanics. AFM topographic images of the same region of a follicle section in PBS (A) and after cystine reduction by DTT (B). Arrows highlight the same distinct features before and after DTT treatment. (C) Representative mechanical mapping along one follicle before (black) and 3 h after addition of 300 mM DTT (red). (D) Boxplots of mean stiffness modulus determined in the matrix of different follicles before and after DTT reduction. The gray lines connect points obtained from the same follicle (n = 9). (E) Boxplots of mean values measured in the differentiated hair (distances > 800 μm) of different follicles before and after addition of DTT (n = 9). (F) Ratio of untreated to treated mean moduli for each individual follicle according to the distance from the bulb along the follicle axis (gray points). Red points show averages within bins of 200 μm.