Fig. 2.

Neuronal expression of Cers2 suppresses Purkinje cell death caused by Cers1-deficiency. (A–F) Calbindin D-28K immunohistochemistry of cerebella from 10-mo-old wild-type (A), Cers1^to/to (B), and Cers1^to/to;Tg-Cers2 (C) mice. Lobule X of each cerebellum was shown in detail (D–F). Sections are close to midline. [Scale bars, 1 mm (A–C) or 100 µm (D–F).] (G–I) Cresyl Violet staining of cerebella from 10-mo-old wild-type (G), Cers1^to/to (H), and Cers1^to/to;Tg-Cers2 (I) mice. Detail in Lobule X was shown. Arrows point to Purkinje cells. (Scale bar, 100 µm.)