Fig. 1.

Inforna enabled a structure-based approach to rationally design a high-affinity, dimeric small molecule that targets the oncogenic miR-96 hairpin precursor. (A) Structure of the miR-96 hairpin precursor. The mature miRNA is written in red letters, and binding sites for 1 and 2 are indicated with a green circle and purple diamond, respectively. (B) Structures of RNA-binding modules 1 (10) and 2. (C) Structures of the designer dimeric compounds, in which RNA-binding modules 1 and 2 are displayed on a peptoid backbone. The number of propylamine spacing modules (n) controls the distance between 1 and 2. The compound with two spacing modules (n = 2) is named Targaprimir-96 (3), the most potent inhibitor of miR-96 processing.