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. 2016 May 11;113(21):5898–5903. doi: 10.1073/pnas.1523975113

Fig. 5.

Fig. 5.

Effect of 3 in 4175 lung metastatic breast cancer cells derived from MDA-MB-231. (A) Effect of 3 (50 nM) on pri-, pre-, and mature miR-96 levels. (B) Effect of 50 nM 3 on FOXO1 protein expression. (C) Ability of 3 (50 nM) to trigger apoptosis with or without forced overexpression of pri-miR-96. (D) Profiling of all miRNAs predicted to target FOXO1 mRNA by using TargetScan (37) in 3-treated 4175 cells. Error bars are the SDs in the measurements. *P < 0.05 as determined by a two-tailed Student t test (n ≥ 3). PI, propidium iodide.