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In vivo studies of 3 on tumor growth in MDA-MB-231 TNBC. (A) Treatment of Nod/Scid mice xenografted with MDA-MB-231-luc cells with 3 inhibits tumor growth. (B) Images of the excised tumors showing decreased tumor size and mass. (C) Effect of 3 on miR-96 biogenesis (Left) and FOXO1 protein levels (Right) in tumors excised from untreated and treated mice. Error bars are the SDs in the measurements. *P < 0.05 as determined by a two-tailed Student t test (n = 5).
