Fig. 3.

Comparison of CDR1 and CDR2 of selected TRAV sequences across mammals. (A) Multiple alignments of TRAV1, TRAV10, TRAV22, and TRAV41 V exons from selected representative species of mammals are shown. CDR1 and CDR2 follow the IMGT definition, and highly conserved motifs in CDR are boxed. The percentage of identity of each sequence to the corresponding human TRAV is given to the right of the alignment. (B) CDR1 and CDR2 were extracted from multiple alignments, and their sequence variation was represented by frequency sequence logos. Note that the TRAV41 logo is based on conserved typical TRAV41 sequences, thus not including human and marsupials, which lack MHX. The Seqlogo of TRAV5 is provided as a control of TRAV not involved in the invariant TR chain.