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. 2016 May 5;113(21):6005–6010. doi: 10.1073/pnas.1601311113

Fig. 4.

Fig. 4.

Frequency of biological background mutations (number of mutations divided by total number of DCS nucleotides) detected in TP53 exons 4–10 and corresponding introns in peritoneal fluid of women with and without ovarian cancer. Patients’ age is indicated in the x axis, and germline BRCA status is color-coded for ovarian cancers and controls. Women without ovarian cancer showed significant associations between the frequency of biological background TP53 mutations and age, both for mutations found in TP53 exons (A) and introns (B). Because control women were segregated into young age and old age depending on germline BRCA status, the correlations with age (regression lines and Spearman’s test P values) are presented separately for women with and without BRCA germline mutations. Women with cancer did not show a significant association between the frequency of biological background TP53 mutations in exons and age (C). For introns, the association was significant after adjusting for BRCA status (D).