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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: DNA Repair (Amst). 2016 Apr 16;42:26–32. doi: 10.1016/j.dnarep.2016.03.016

Figure 4. Effects of siRNA knockdown of MMR pathway genes on the percentages of ATR-S428P positive cells.

Figure 4

(A) Representative images of ATR foci formed after vimentin and MSH2 knockdown in DIT7 cells. DAPI stained cells are shown on the left and ATR-S428P foci formed during convergent transcription are shown on the right (B) The percentages of cells positive for ATR-S428P staining were determined after knockdown of vimentin (30%), MSH2-1 (5%), MSH3-1 (3%) and MLH1 (4.5%). Data are the average of 1000 cells from each randomly selected field from 3 independent coverslips. Error bars represent standard deviations in each case. P values are indicated ★P<0.05, ★★P<0.01, ★★★P<0.001.