Table 2. Significant (P < 0.05) association (measured genotype approach) of SNPs with key MS-related phenotypes.
SNP | MAF (%) | Location (bp) | HDL-C | ln Leptin | FPG | FSI | SS | T2DM | BMI | ln TG | Total |
---|---|---|---|---|---|---|---|---|---|---|---|
rs1800949 | 29.9 | −768 | 0.038 | 1 | |||||||
rs876507 | 1.1 | 2,330 | 0.042 | 1 | |||||||
rs4086314 | 28.8 | 3,407 | 0.027 | 1 | |||||||
rs6918013 | 6.4 | 9,386 | 0.032 | 0.0047 | 2 | ||||||
rs943004 | 4.4 | 11,544 | 0.046 | 1 | |||||||
rs7756163 | 48.2 | 13,331 | 0.048 | 1 | |||||||
rs6917903 | 30.7 | 18,284 | 0.010 | 1 | |||||||
rs1830971 | 41.3 | 19,021 | 0.0096 | 1 | |||||||
rs2021966 | 49.8 | 21,107 | 0.038 | 0.041 | 2 | ||||||
rs9372999 | 10.6 | 23,820 | 0.0068 | 1 | |||||||
rs7754609 | 7.9 | 25,598 | 0.020 | 1 | |||||||
rs997509 | 1.8 | 38,645 | 0.045 | 1 | |||||||
rs7769058 | 5.5 | 63,662 | 0.039 | 1 | |||||||
rs7769712 | 9.2 | 64,063 | 0.037 | 1 | |||||||
rs6928362 | 2.5 | 81,349 | 0.012 | 0.032 | 2 | ||||||
rs1974201 | 43.3 | 81,789 | 0.045 | 1 | |||||||
rs6929388 | 2.5 | 81,858 | 0.015 | 0.049 | 2 | ||||||
rs7754586 | 44.9 | 83,410 | 0.013 | 1 | |||||||
rs7754859 | 47.2 | 83,476 | 0.042 | 1 | |||||||
rs1931009 | 5.8 | 85,336 | 0.044 | 1 | |||||||
Total | 7 | 6 | 4 | 1 | 2 | 2 | 1 | 1 | 24 |
FPG, fasting plasma glucose; FSI, fasting-specific insulin; HDL-C, high-density lipoprotein cholesterol; ln, natural log-transformed; MAF, minor allele frequency; MS, metabolic syndrome; SNP, single-nucleotide polymorphisms; SS, sum of skinfold thickness; T2DM, type 2 diabetes mellitus; TG, triglyceride.
P values <0.01 are indicated in boldface.