Skip to main content
. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Cell Rep. 2016 May 19;15(9):1876–1883. doi: 10.1016/j.celrep.2016.04.083

FIGURE 2. Global Single nucleotide-resolution IGF2BP3-RNA interaction map.

FIGURE 2

A. Bar graph showing genomic distribution of IGF2BP3 from PDAC cell lines, hnRNPA1 (HEK293 cells) and simulated (hg19 background) crosslinking sites. The bars represent the average of replicate experiments (N=2 from PL45; N=1 from PANC1), respectively. Standard deviations are indicated by error bars. B. Distribution of peaks called from IGF2BP3-, hnRNPA1- and simulated crosslinking sites within mRNA. C. Meta-analysis of IGF2BP3 and hnRNPA1 iCLIP crosslink sites relative to the stop codon. Relative crosslinking density (normalized count) is shown −/+ SEM. D. IGF2BP3 crosslinking density from PDAC cell lines mapped relative to annotated miRNA target sites. hnRNPA1 crosslinking sites from HEK293 cells are included as a control. E. Over represented pentamers found near IGF2BP3 crosslinking sites in PDAC cells.