Table 3.
Association between genotype on SNPs not previously reported on and suicidal behavior or MDD in live and postmortem subjects (only SNPs with uncorrected p<0.05 are listed). All models were adjusted by age and sex.
Y=attempted suicide/suicide death | Y=MDD | |||||||
---|---|---|---|---|---|---|---|---|
postmortem | live | live | live | |||||
Genes | SNPs | suicide death(n=121)vs sudden death(n=88) |
suicide attempter (n=87) vs non-attempter (n=190) |
MDD attempter (n=87) vs MDD non-attempter (n=132) |
MDD(n=219) vs healthy volunteer n=56) |
|||
p-value | risk genotype |
p-value | risk genotype |
p-value | risk genotype |
p-value | ||
FKBP5 | rs7757037 | 0.718 | 0.033 | AA | 0.044 | AA | 0.471 | |
rs737054 | 0.726 | 0.049 | AA | 0.084 | 0.293 | |||
rs9380529 | 0.053 | 0.011 | GG | 0.011 | GG | 0.657 | ||
SKA2 | rs8082544 | 0.036 | AG | 0.638 | 0.929 | 0.278 | ||
rs12945875 | 0.636 | 0.306 | 0.024 | AA | 0.358 | |||
rs9911583 | 0.543 | 0.014 | GG | 0.008 | GG | 0.665 | ||
rs8067682 | 0.488 | 0.081 | 0.043 | AA | 0.597 | |||
rs7502947 | 0.013 | AG | 0.401 | 0.754 | 0.229 | |||
NR3C1 | rs9324924 | 0.295 | 0.078 | 0.037 | AC | 0.402 |