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. Author manuscript; available in PMC: 2016 Aug 12.
Published in final edited form as: Leukemia. 2016 Feb 12;30(6):1335–1343. doi: 10.1038/leu.2016.14

Figure 6. Efficacy of Akt inhibition in Nf1Δ/− mice.

Figure 6

(A) White blood cell (WBC) counts, (B) hemoglobin (Hb) concentrations, and (C) reticulocyte counts in peripheral blood of Nf1Δ/− and control mice sampled weekly during MK-2206 treatment. Statistical analysis was performed as described in Figure 4. Cohort sizes: Nf1 vehicle: 5; Nf1 MK-2206: 4; Nf1 PD0325901: 7; Nf1 combination: 7; control vehicle: 6; control MK-2206: 5; control PD0325901: 7; control combination: 3. (D) Spleen weights in mice measured at time of death or trial end, analyzed as in Figure 4D.