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. Author manuscript; available in PMC: 2017 May 31.
Published in final edited form as: Circulation. 2016 May 6;133(22):2169–2179. doi: 10.1161/CIRCULATIONAHA.115.020633

Figure 5.

Figure 5

Protective effects of ASA are inhibited in Fpr2/3−/− mice. Wild type (WT, C57Bl/6) and Fpr2/3−/− mice were subjected to MCAo for 60 min, followed by 24 h reperfusion. Vehicle (V. saline) or ASA (150 mg/kg) were administered 60 min prior to I/R. A+E) Plasma ATL levels; B+F) ATL levels in whole brain homogenates; C+G) adherent leukocytes and D+H) NPAs were measured in WT and Fpr2/3−/− mice. Data are mean ± SEM of 6–8 mice per group. **p < 0.01 & ***p < 0.001 vs. vehicle. ###p < 0.001 vs. ASA.