TABLE 5.
Factors associated with postoperative seizures in patients with supratentorial meningioma
| Factor | Patients w/Preop Seizures
|
Patients w/o Preop Seizures
|
Included Studies | ||||
|---|---|---|---|---|---|---|---|
| Persistent Seizures | Seizure Free | p Value | New Seizures | No New Seizures | p Value | ||
| Sex | 0.48 | 0.18 | 9, 26, 28, 37, 60, 62, 69, 70 | ||||
|
| |||||||
| Female | 68 (26.8) | 186 (73.2) | 6 (2.6) | 229 (97.4) | |||
|
| |||||||
| Male | 41 (30.1) | 95 (69.9) | 5 (5.6) | 84 (94.4) | |||
|
| |||||||
| Age | 0.99 | 0.99 | 3, 5, 9, 12, 18, 20, 26, 28, 35, 37, 43, 53, 60, 62, 68–70 | ||||
|
| |||||||
| <18 yrs | 1 (20.0) | 4 (80.0) | 0 (0.0) | 12 (100.0) | |||
|
| |||||||
| ≥18 yrs | 149 (24.4) | 461 (75.6) | 16 (3.8) | 404 (96.2) | |||
|
| |||||||
| Side | 0.80 | NA | NA | 26, 28, 37, 62, 69 | |||
|
| |||||||
| Lt | 46 (25.3) | 136 (74.7) | |||||
|
| |||||||
| Rt | 38 (28.1) | 97 (71.9) | |||||
|
| |||||||
| Midline/bilat | 1 (20.0) | 4 (80.0) | |||||
|
| |||||||
| Neurological deficit | 0.57 | 0.43 | 9, 69, 70 | ||||
|
| |||||||
| Yes | 16 (39.0) | 25 (61.0) | 3 (10.7) | 25 (89.3) | |||
|
| |||||||
| No | 40 (33.6) | 79 (66.4) | 5 (6.3) | 74 (93.7) | |||
|
| |||||||
| Peritumoral edema | <0.001* | 0.99 | 26, 37, 62 | ||||
|
| |||||||
| Yes | 30 (35.7) | 54 (64.3) | 1 (20.0) | 4 (80.0) | |||
|
| |||||||
| No | 23 (15.8) | 123 (84.2) | 1 (11.1) | 8 (88.9) | |||
|
| |||||||
| Pathology | 0.22 | 0.42 | 5, 9, 12, 18, 26, 37, 60, 70 | ||||
|
| |||||||
| WHO I | 101 (22.1) | 356 (77.9) | 6 (2.7) | 217 (97.3) | |||
|
| |||||||
| WHO II–III | 6 (37.5) | 10 (62.5) | 3 (4.7) | 61 (95.3) | |||
|
| |||||||
| Location | <0.05* | 0.22 | 9, 20, 26, 28, 37, 43, 60, 62, 69, 70 | ||||
|
| |||||||
| Convexity | 47 (31.5) | 102 (68.5) | 8 (3.3) | 234 (96.7) | |||
|
| |||||||
| Parasagittal/falx | 26 (25.5) | 76 (74.5) | 1 (33.3) | 2 (66.7) | |||
|
| |||||||
| Sphenoid wing | 18 (45.0) | 22 (55.0) | 2 (6.5) | 29 (93.5) | |||
|
| |||||||
| Olfactory groove | 5 (17.9) | 23 (82.1) | 2 (5.3) | 36 (94.7) | |||
|
| |||||||
| Planum/tuberculum | 5 (17.9) | 23 (82.1) | 0 (0.0) | 24 (100.0) | |||
|
| |||||||
| Tentorial | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (100.0) | |||
|
| |||||||
| Intraventricular | 1 (33.3) | 2 (66.7) | 0 (0.0) | 1 (100.0) | |||
|
| |||||||
| Petroclival | 0 (0.0) | 7 (100.0) | 0 (0.0) | 3 (100.0) | |||
|
| |||||||
| Size | 0.99 | 0.16 | 26, 28, 62 | ||||
|
| |||||||
| ≤4 cm | 0 (0.0) | 3 (100.0) | 1 (2.9) | 33 (97.1) | |||
|
| |||||||
| >4 cm | 1 (20.0) | 4 (80.0) | 1 (33.3) | 2 (66.7) | |||
|
| |||||||
| Seizure type | 0.14 | NA | NA | 9, 26, 69 | |||
|
| |||||||
| Partial only | 21 (28.4) | 53 (71.6) | |||||
|
| |||||||
| Generalized | 36 (39.6) | 55 (60.4) | |||||
|
| |||||||
| Previous radiation | 0.29 | <0.01* | 9, 26, 60, 69 | ||||
|
| |||||||
| Yes | 8 (47.1) | 9 (52.9) | 5 (13.2) | 33 (86.8) | |||
|
| |||||||
| No | 49 (33.1) | 99 (66.9) | 4 (1.7) | 233 (98.3) | |||
|
| |||||||
| AED prophylaxis | NA | NA | 0.99 | 3, 9, 35, 48, 60, 68 | |||
|
| |||||||
| Yes | 55 (13.7) | 346 (86.3) | |||||
|
| |||||||
| No | 17 (13.2) | 112 (86.8) | |||||
|
| |||||||
| Extent of resection | 0.18 | 0.02* | 9, 26, 28, 37, 60, 62, 70 | ||||
|
| |||||||
| Gross-total | 91 (26.8) | 249 (73.2) | 6 (2.2) | 268 (97.8) | |||
|
| |||||||
| Subtotal | 18 (36.0) | 32 (64.0) | 5 (10.0) | 45 (90.0) | |||
|
| |||||||
| Tumor progression | <0.05* | <0.05* | 9, 37 | ||||
|
| |||||||
| Yes | 25 (38.5) | 40 (61.5) | 4 (21.1) | 15 (78.9) | |||
|
| |||||||
| No | 83 (26.2) | 234 (73.8) | 4 (5.3) | 72 (94.7) | |||
NA = not available.
*
p < 0.05, chi-square test.