Table 4a.
Net-reclassification (NRI)* of 10-year risk of CHD among WHI OS participants with and without incident CHD after adding significant reproductive factors to the established CHD risk factor model.
| Established CHD risk factors plus significant reproductive factors† model | ||||||||
|---|---|---|---|---|---|---|---|---|
| Low risk
(0–5%) |
Intermediate risk
(>5–10%) |
High risk
(>10%) |
Total | |||||
| Established CHD risk factor model** | N | % | N | % | N | % | N | % |
| Participants with incident CHD | ||||||||
| 0–5% | 1281 | 89.02 | 158 | 10.98 | 0 | 0.00 | 1439 | 31.2 |
| >5–10% | 144 | 8.00 | 1501 | 83.34 | 156 | 8.66 | 1801 | 39.1 |
| >10% | 0 | 0.00 | 137 | 10.2 | 1230 | 89.98 | 1367 | 29.7 |
| Total | 1425 | 30.9 | 1796 | 39.0 | 1386 | 30.1 | 4607 | – |
| Participants with no incident CHD | ||||||||
| 0–5% | 40040 | 95.25 | 1996 | 4.75 | 0 | 0.00 | 42036 | 61.5 |
| >5–10% | 1929 | 10.52 | 15306 | 83.45 | 1106 | 6.03 | 18341 | 26.8 |
| >10% | 0 | 0.00 | 1014 | 12.68 | 6984 | 87.32 | 7998 | 11.7 |
| Total | 41969 | 61.4 | 18316 | 26.79 | 8090 | 11.83 | 68375 | – |
NRI = 0.005, 95% CI: −0.006, 0.015; p-value = 0.37
NRI events = 0.007, 95% CI: −0.003, 0.018; p-value = 0.18
NRI for non-events = 0.002, 95% CI: 0.0001, 0.005; p-value = 0.04
Integrated discrimination improvement = 0.0013, 95% CI: 0.0008, 0.0017; p-value < 0.0001
Survival measures were used to estimate reclassification statistics10
Established risk factors modeled include age, high cholesterol requiring pills, hypertension medications, log of systolic blood pressure, current smoker, diabetes.
Significant pregnancy risk factors include age at first birth, still births, miscarriages, and breastfeeding ≥ 1 month.