IPA-3 inhibits prostate cancer cell proliferation. (A-C) Dose- and time-dependent effect of free IPA-3 on MTT staining in human prostate cancer PC-3, LNCaP and DU-145 cells, respectively, 24, 48, and 72 hrs after treatment (n = 3). (D and E)Effect of free IPA-3 and SSL-IPA-3 on MTT staining in human prostate cancer PC-3 and DU-145 cells, respectively, 72 hrs after treatment(n = 3). The white bars in Figure 1D and E for control indicate the effect of empty liposomes. Data are presented as the mean ± SEM of the fold change in MTT staining as function of IPA-3 concentration;*p <0.05; “NS” indicates not significant.