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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Nanomedicine. 2016 Mar 3;12(5):1231–1239. doi: 10.1016/j.nano.2016.01.003

Figure 4.

Figure 4

Sterically stabilizedliposome- encapsulated IPA-3 (SSL-IPA-3) significantly inhibits prostate tumor xenograft growth in vivo. (A)Pictures of athymic nude mice bearing PC-3 cell tumor xenografts and treated with vehicle (DMSO), empty liposomes, IPA-3or liposome encapsulated IPA-3 (SSL-IPA-3). (B)Histogram showing the weight of PC-3 cell tumor xenografts collected from athymic nude mice treated with vehicle (DMSO), empty liposomes, IPA-3or liposome encapsulated IPA-3 on day 25 after tumor implantation and day 18 after the start of treatments (n = 5-6). (C)Histogram showing the volume of PC-3 cell tumor xenografts on day 7, 14, 21 and 25 after implantation in athymic nude mice treated with vehicle (DMSO), empty liposomes, IPA-3or liposome encapsulated IPA-3 as measured using calipers (n = 5-6). (D)Histogram showing the body weight of the PC-3 cell tumor bearing athymic nude mice on day 25 after tumor implantation and day 18 after treatment with vehicle (DMSO), empty liposomes, IPA-3or liposome encapsulated IPA-3. Data are presented as the mean ± SEM; #p < 0.01.