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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Cell Rep. 2016 May 19;15(9):1986–1999. doi: 10.1016/j.celrep.2016.04.078

Figure 6. Immunization with JRFL SOSIP trimer-conjugated liposomes induced enhanced germinal center (GC) formation.

Figure 6

(A) Three groups of five C57Bl/6 mice were subcutaneously administered PBS, soluble JRFL SOSIP trimers or JRFL SOSIP trimer-conjugated liposomes. After 14 days, lymph node B cells were analysed for the activation marker, GL7. The percentage of CD19+ GL7+ cells are enumerated. (B) Representative flow cytometry scatter plots from each group of mice shown in (A) were gated over CD19+ cells from lymph nodes. (C) Two groups of five C57Bl/6 mice were subcutaneously administered either blank liposomes or JRFL SOSIP trimer-conjugated liposomes. After 14 days, the lymph nodes are processed and the percentages of CD19+ GL7+ cells are enumerated. P values were calculated with a two-tailed unpaired t test.