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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Cell Rep. 2016 May 19;15(9):2025–2037. doi: 10.1016/j.celrep.2016.04.018

Figure 7. Model for SLNCR1-induced MMP9 transcriptional upregulation.

Figure 7

When SLNCR1 increases, AR and Brn3a bind to conserved, adjacent regions of SLNCR1. The SLNCR1/AR/Brn3a ternary complex has high affinity for adjacent Brn3a and AR binding sites located upstream of the MMP9 transcriptional start site. Cooperative binding of AR and Brn3a to its promoter increases MMP9 expression and activity and thus increases invasion of melanoma cells. See also Figures S7.