A low level of DA expression sustains in the lumbosacral spinal cord after SCI. DA expression in the dorsal half of L6–S3 spinal segments was measured by ELISA in the intact or T10–Tx spinal cord. DA levels significantly decrease 1 week following injury (one-way ANOVA, followed by Fischer’s PLSD, ***p < 0.001). After 3 weeks, however, an appreciable level of DA (approximately 10% of baseline level) is still detected, even though supraspinal TH+ projections below the lesion have completely degenerated. This low level of DA expression persists in 6 weeks post-injury and is not significantly different than levels found 3 weeks after SCI.