Figure 1.

Evolution of neuronal axonal injury and hyperexcitability after traumatic brain injury (TBI). The schematic figure summarizes events occurring during the progression of axonal injury from acute post-injury periods (minutes to hours), through to late post-injury periods (weeks to months). Also presented is a summary of known electrophysiological changes in neuronal excitability in cortex after TBI, and the time-points at which they occur.