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Scheme of PKC/ROS signaling pathways involved in OLs differentiation. ROS produced by NOX3/5 amplify PMA activated PKC, ERK1-2 and CREB signaling increasing the expression of the differentiation markers MBP and Olig-2. In the figure is also depicted the possible role of NOX3/5 derived ROS in the stabilization of membrane receptor(s) leading to OLs differentiation.
