Table I.
Recommendations for concomitant drug use (prepared on the basis of the review by Ahmad [133])
| Statin | Dose | Concomitant drug |
|---|---|---|
| Pravastatin | ≤ 20 mg/day | Cyclosporine |
| ≤ 40 mg/day | Macrolide antibiotics | |
| Any dose | Antifungals, protease inhibitor, amiodarone, verapamil and dilitiazem, amlodipine, ranolazine, dronedarone, rifampin | |
| Fluvastatin | ≤ 20 mg/day | Cyclosporine, antifungals |
| Any dose | Macrolide antibiotics, protease inhibitor, amiodarone, verapamil and dilitiazem, amlodipine, ranolazine, dronedarone, rifampin | |
| Rosuvastatin | ≤ 5 mg/day | Cyclosporine |
| Any dose | Antifungals, macrolide antibiotics, protease inhibitor, amiodarone, verapamil and dilitiazem, amlodipine, ranolazine, dronedarone, rifampin | |
| Atorvastatin | ≤ 20 mg/day | Antifungals, macrolide antibiotics, amlodipine |
| Any dose | Amiodarone, verapamil and dilitiazem, ranolazine, dronedarone, rifampin | |
| Simvastatin, amlodipine (The dose of 20 mg of simvastatin should not be exceeded when used in combination with amlodipine) | Any dose | Rifampin |
| ≤ 10 mg/day | Verapamil and dilitiazem, dronedarone | |
| ≤ 20 mg/day | Amiodarone, ranolazine | |
| Lovastatin | ≤ 40 mg/day | Amiodarone |
| Any dose | Amlodipine, ranolazine, dronedarone, rifampin | |
| Pitavastatin | Any dose | Antifungals, amiodarone, calcium antagonists, dronedarone, protease inhibitors, ranolazine |
| ≤ 1 mg/day | Macrolide antibiotics | |
| ≤ 2 mg/day | Rifampin |