Figure 2.

Effect of dietary feeding of DFMO, licofelone, and the combination on NNK-induced lung tumor growth in A/J mice. A. Lung tumors from different groups at the 17-week post diet treatment stage. B. Lung tumors from different groups at the 34-week post diet treatment stage. Effect of DFMO, licofelone, and the combination on NNK-induced lung adenoma in A/J mice. C. Lung adenoma from different groups at the 17-week post diet treatment stage. D. Lung adenoma from different groups at the 34-week post diet treatment stage. Values are means ± SE with N = 10. Effect of DFMO, licofelone, and the combination on NNK-induced lung adenocarcinoma in A/J mice. E. Lung adenocarcinoma from different groups at the 17-week post diet treatment stage. F. Lung adenocarcinoma from different groups at the 34-week post diet treatment stage. Values are means ± SE with N = 15. Differences between control and treatment groups were analyzed by one-tailed t-test with Welch correction and 95% confidence interval. G. Representative photomicrograph of hematoxylin and eosin (H&E) staining of lung tumor sections from mice in different experimental groups.