Figure 3.

Effect of DFMO, licofelone, and the combination on ODC, 5-Lox, Cox-2, mPGES-1, and FLAP mRNA expression in NNK-induced lung tumor from mice in different treatment groups. Relative mRNA expression of ODC, 5-Lox, Cox-2, mPGES-1, and FLAP in RNA samples from different treatment groups as analyzed by real-time PCR and normalized to β-actin. Significance of differences between control and treatment groups was analyzed by one-tailed t-test with Welch correction and 95% confidence interval. Data with means ± SE. p ≤ 0.05 was considered statistically significant.