Figure 5.

Effect of DFMO, licofelone, and the combination on the polyamine synthesis pathway. Relative mRNA expression of spermidine synthase (SRM), spermine synthase (SMS), spermidine N(1)-acetyl transferase (SAT), ornithine amino transferase (Oat), and antizyme (Oaz) in RNA samples from different treatment groups as analyzed by real-time PCR and normalized to β-actin. Differences between control and treatment groups were analyzed by one-tailed t-test with Welch correction and 95% confidence interval. Data represent means ± SE. p ≤ 0.05 was considered statistically significant.