Figure 7.

Effect of DFMO, licofelone, and the combination on p53, p21, Bax, and p27. A. Representative photomicrographs showing immunohistochemical detection of p53 and p21 (magnification ×600; inset shows 400× magnification). B. Relative mRNA expression of p53, p21, Bax, and p27 in RNA samples from different treatment groups as analyzed by real-time PCR and normalized to β-actin. Differences between control and treatment groups were analyzed by one-tailed t-test with Welch correction and 95% confidence interval. Data represent means ± SE. p ≤ 0.05 was considered statistically significant.