Figure 8.

Effect of DFMO, licofelone, and the combination on pro-inflammatory cytokine and MMPs. Relative mRNA expression of (A) IL-1β, IL-6, TNF-α, and (B) MMP-2, MMP-7, MMP-9 and MMP-13, in RNA samples from different treatment groups as analyzed by real-time PCR and normalized to β-actin. Differences between control and treatment groups were analyzed by one-tailed t-test with Welch correction and 95% confidence interval. Data represent means ± SE. p ≤ 0.05 was considered statistically significant.