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. 2016 May 1;6(5):924–936.

Figure 6.

Figure 6

SP+N: SP600125+NDV; SP+R: SP600125+rL-RVG. The autophagy induced by rL-RVG was mediated by the IRE1/JNK/beclin-1 signaling pathway. A. For SGC; B. For HGC. The phosphorylation of JNK and bcl-2 was upregulated in the rL-RVG- or NDV-infected SGC and HGC cells. The expression of the autophagy-associated proteins beclin-1 and LC3-II/I decreased in cells after treatment with a specific inhibitor of JNK, or SP600125, compared with cells without the treatment. The same was observed for apoptosis-associated proteins. C. The ultrastructure of the SGC cells after infection with virus or pretreatment with SP600125. rL-RVG infection increased the number of autophagosomes in SGC cells, but the number of rL-RVG-induced autophagosomes was markedly decreased after pretreatment with SP600125.