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. 2016 May 1;6(5):981–995.

Figure 6.

Figure 6

Lapatinib prevented early stage breast lesion progression in MMTV-neu* mouse model. A. Kaplan-Meier Survival analysis of MMTV-neu* mice treated with Vehicle and 30 mg/kg Lapatinib for prevention. B. Representative H&E and IHC images of pErbB2 (Y1248), Ki-67, cleaved caspase-3, p-Akt (S473), Cyclin D2 and GLUT4 staining in the mammary gland from FVB control mice and MMTV-neu* mice treated with Vehicle or 30 mg/kg lapatinib. H&E images (for both Vehicle and Lapatinib treatment) were from samples collected at 21 weeks and IHC staining was done on samples collected at end point. Scale bar represents 50 µm. C. Quantitative analysis of IHC staining intensity scores of various markers in vehicle and lapatinib treated MMTV-neu* mice along with WT FVB mice as shown in B. *, P < 0.05, **, P < 0.01 and ***, P < 0.001.