Table 2.
Tissue distribution of 131I-labelled scFv antibody in tumor-bearing mice (n=3)
| Tissue | 6 h | 12 h | 24 h | 48 h |
|---|---|---|---|---|
| Tumor | 22.98 ± 2.85 | 10.74 ± 0.98 | 6.39 ± 0.54 | 1.41 ± 0.15 |
| Blood | 21.28 ± 1.63 | 7.37 ± 1.35 | 2.24 ± 0.64 | 0.90 ± 0.08 |
| Heart | 13.41 ± 1.38 | 6.02 ± 1.26 | 1.67 ± 0.19 | 0.61 ± 0.15 |
| Liver | 20.67 ± 2.18 | 11.03 ± 1.08 | 5.68 ± 0.34 | 1.35 ± 0.19 |
| Spleen | 18.81 ± 2.71 | 9.20 ± 1.90 | 4.25 ± 0.49 | 0.92 ± 0.19 |
| Lung | 17.41 ± 2.60 | 9.01 ± 1.39 | 3.35 ± 0.56 | 0.89 ± 0.04 |
| Kidney | 21.38 ± 1.59 | 14.02 ± 1.45 | 7.86 ± 0.42 | 1.77 ± 0.33 |
| Brain | 2.16 ± 0.60 | 0.74 ± 0.11 | 0.27 ± 0.02 | 0.07 ± 0.01 |
| Intestine | 18.58 ± 1.15 | 13.19 ± 1.04 | 6.20 ± 0.14 | 1.33 ± 0.29 |
| Bone | 12.22 ± 1.39 | 5.75 ± 1.00 | 2.15 ± 0.16 | 0.69 ± 0.15 |
| Muscle | 7.72 ± 1.05 | 3.40 ± 0.34 | 1.49 ± 0.20 | 0.43 ± 0.05 |
| Ratio | ||||
| Tumor/brain | 12.08 ± 2.93 | 14.92 ± 1.91 | 23.65 ± 3.00 | 21.65 ± 4.95 |
| Tumor/muscle | 3.09 ± 0.54 | 3.17 ± 0.17 | 4.51 ± 0.89 | 3.37 ± 0.62 |
| Tumor/blood | 1.08 ± 0.10 | 1.61 ± 0.44 | 3.45 ± 1.06 | 1.61 ± 0.30 |
Note: Tissue uptakes are expressed as percent injected dose per gram (% ID/g ± SEM).