Table 1.
The mRNA level of MLH1 in HNPCC family members
| Family number | Mutation | Expression level of MLH1* |
|---|---|---|
| H2-1 | MLH1 mutation | 4.3436 × 10-3 |
| -2 | MLH1 mutation | 5.4375 × 10-3 |
| -3 | MLH1 mutation | 4.6078 × 10-1 |
| -4 | No mutation | 6.4324 × 10-1 |
| H11-1 | MSH2 mutation | 7.3112 × 10-3 |
| -2 | No mutation | 2.3719 × 10-1 |
| H17 | No mutation | NR |
| H21-1 | No mutation | 4.1852 |
| -2 | No mutation | 27.351 |
| H27-1 | No mutation | NA |
| -2 | No mutation | NA |
| -3 | No mutation | 51.671 |
| H28-1 | No mutation | 37.964 |
| -2 | No mutation | 1.9153 × 10-5 |
| -3 | No mutation | 46.278 |
| H31-1 | MLH1 mutation | 3.1153 × 10-1 |
| -2 | MLH1 mutation | 3.2621 × 10-1 |
| -3 | No mutation | 4.7874 |
| H32-1 | No mutation | 29.436 |
| -2 | No mutation | 3.3179 |
| -3 | No mutation | 18.794 |
| H38 | MSH2 mutation | 8.7201 |
| H45-1 | MLH1 mutation | 2.9774 × 10-6 |
| -2 | MLH1 mutation | 2.9723 × 10-5 |
| -3 | No mutation | NA |
| -4 | MLH1mutation | NA |
| H65-1 | MSH2 mutation | 2.5410 × 10-3 |
| -2 | MSH2 mutation | 3.3278 × 10-1 |
| H68-1 | MLH1 mutation | 4.4365 × 10-1 |
| -2 | No mutation | NR |
| H99-1 | MSH2 mutation | 8.8604 × 10-3 |
| -2 | MSH2 mutation | 3.4362 × 10-2 |
| -3 | No mutation | 5.6140 × 10-1 |
| H111-1 | MLH1 mutation | 7.4573 × 10-1 |
| -2 | No mutation | 6.3657 |
| H114-1 | MLH1 mutation | 3.2365 |
| -2 | No mutation | 4.7321 |
*
NR, no result. NA, sample absence.