Table 6.

Average pupillary pulsed light evaluation response score using pupillary light reflexes to identify diabetes complicated by pupillary autonomic dysfunction^*

Variable	β-coefficient (95% CI)	Adjusted† OR (95% CI)	Points
Baseline pupillary radius
≤ 22.80	0.00	1.00	0
> 22.80	0.98 (−0.13, 2.09)	4.24 (1.67, 10.75)	2
Latency to onset of constriction
≤ 0.22	0.00	1.00	0
> 0.22	1.44 (0.51, 2.38)	3.79 (1.55, 9.29)	3
Maximum constriction velocity
≤ −3260.39	0.00	1.00	0
> −3260.39	0.69 (−0.45, 1.83)	1.99 (0.64, 6.25)	1.5
Sex
Male	0.00	1.00	0
Female	0.17 (−0.76, 1.09)	1.18 (0.47, 2.98)	0.5
Age
≤ 47 years	0.00	1.00	0
> 47 years	0.52 (−0.38, 1.42)	1.69 (0.69, 4.14)	1
AUC
Uncorrected AUC‡	0.77 (0.70, 0.85)
Optimism-corrected AUC‡	0.71 (0.62, 0.79)

AUC = area under the ROC curve; 95% CI = 95% confidence interval; OR = odds ratio; ROC = receiver operating curve.

^*Units for pupillometric variables were pixels for static distances, seconds for time, and pixels per second for velocity metrics.

^†Adjusted for the other parameters included in the logistic regression model (parameters shown).

^‡Area under the ROC curve (95% CI).