Table 7.

APPLE response score as a clinical predictor of diabetes, sensitivity, specificity, and likelihood ratios (LRs)

Cutoff points	Sensitivity (%)	Specificity (%)	Correctly classified (%)	LR+	LR−
≥ 5.0	93.9	54.6	63.2	2.07	0.11
≥ 5.5	87.9	61.3	67.1	2.27	0.20
≥ 6.0	81.8	63.9	67.8	2.26	0.28
≥ 6.5	78.8	66.4	69.1	2.34	0.32
≥ 7.0	72.7	68.1	69.1	2.28	0.40
≥ 7.5	51.5	79.0	73.0	2.45	0.61
≥ 8.0	45.5	81.5	73.7	2.46	0.67

APPLE = average pupillary pulsed light evaluation; LR+ = positive likelihood ratio, LR− = negative likelihood ratio.