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. 2016 Jun;137(6):1898–1902.e7. doi: 10.1016/j.jaci.2015.11.047

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig E1 — Decreased IL-9 production in NFATc1^fl/flxCD4Cre mice after allergen sensitization and challenge. A, Experimental design of the OVA-induced asthma model. B, IL-9 protein concentrations were measured in supernatants of purified lung CD4⁺ T cells from allergen-treated mice and cultured for 24 hours with α-CD3 and α-CD28 antibodies (n = 7-11 mice per group). C,Irf4 mRNA expression measured by using quantitative real-time PCR in isolated lung CD4⁺ T cells (n = 8-13 mice per group). D, Correlation between Nfatc1/A mRNA expression in lung CD4⁺ T cells and OVA-specific IgE levels in serum of Nfatc1^fl/fl OVA-treated mice (n = 6). E, Correlation between Irf4 mRNA expression in lung CD4⁺ T cells and OVA-specific IgE in serum of Nfatc1^fl/fl OVA mice (n = 6). The Student t test was used to evaluate statistical significance. *P ≤ .05. Data are presented as means ± SEMs.