Table II.

Net change in IgE sensitization (>0.35 kU_A/L) to house dust mite, grass, and cat and total IgE levels (kilounits per liter) over 20 years by year-of-birth cohort

	1964-1973 (n = 736)			1954-1963 (n = 1314)			1944-1953 (n = 1156)
Prevalence (%) or GM	Net change (95% CI)		Prevalence (%) or GM	Net change (95% CI)		Prevalence (%) or GM	Net change (95% CI)
ECRHS I	ECRHS II vs I	ECRHS III vs I	ECRHS I	ECRHS II vs I	ECRHS III vs I	ECRHS I	ECRHS II vs I	ECRHS III vs I
House dust mite	18.6	−0.6 (−3.0 to 1.8)	−4.1 (−6.7 to −1.5)	17.2	0.2 (−1.9 to 2.4)	−4.5 (−6.9 to −2.1)	13.8	−2.0 (−3.9 to −0.1)	−4.3 (−6.6 to −1.9)
Grass	20.6	3.3 (0.4 to 6.2)	1.5 (−1.8 to 4.9)	15.9	0.5 (−1.4 to 2.3)	−0.1 (−2.5 to 2.3)	15.4	−1.9 (−3.8 to 0.0)	−3.2 (−5.3 to −1.0)
Cat	10.5	0.2 (−2.2 to 2.6)	−0.7 (−3.5 to 2.0)	8.3	−1.4 (−2.9 to 0.1)	−2.0 (−3.6 to −0.3)	8.1	−1.2 (−2.7 to 0.2)	−3.6 (−5.2 to −2.0)
House dust mite, grass, or cat	33.5	1.9 (−1.3 to 5.1)	−2.1 (−6.1 to 1.9)	28.7	1.1 (−1.6 to 3.7)	−4.1 (−7.2 to −1.1)	26.5	−3.0 (−5.6 to −0.3)	−7.4 (−10.4 to −4.3)
Total IgE	29.9	0.81 (0.72 to 0.91)	0.61 (0.54 to 0.68)	31.3	0.85 (0.78 to 0.92)	0.61 (0.56 to 0.67)	27.9	0.84 (0.78 to 0.92)	0.68 (0.61 to 0.75)