Table 2.

Enriched KEGG pathways in down- and upregulated genes (fold change > 1.7; p < 0.05).Only categories significantly associated (p value < 0.05) are considered. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, number of enriched genes, p value, enrichment factor, and list of the genes enriched in each pathway are reported.

KEGG pathway	Number of genes	p value	Enrichment factor	Gene list
Gene set: downregulated genes
Tight junction	2	0.0261	8.0	Actn3, Csda
Melanogenesis	3	8.18E − 4	16.5	Camk2b, Gnas, and Prkaca
Long-term depression	2	0.00871	14.3	Ryr1, Gnas
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2	0.00789	15.0	Cacnb1, Actn3
GnRH signaling pathway	3	7.52E − 4	17.0	Camk2b, Gnas, and Prkaca
Prostate cancer	2	0.0119	12.2	Hsp90ab1, E2f2
Gap junction	2	0.0119	12.2	Gnas, Prkaca
Galactose metabolism	2	0.00103	42.4	Gaa, Pfkm
Glioma	2	0.00692	16.1	E2f2, Camk2b
Dilated cardiomyopathy	3	5.91E − 4	18.4	Cacnb1, Gnas, and Prkaca
Metabolic pathways	9	2.11E − 4	4.34	Adssl1, St3gal3, Cox10, Gaa, Atp6v0a1, Gamt, Pfkm, Ndufa10, and Idh3a
Oxidative phosphorylation	3	0.00266	10.9	Cox10, Atp6v0a1, and Ndufa10
Calcium signaling pathway	4	3.64E − 4	11.9	Ryr1, Camk2b, Gnas, and Prkaca
Insulin signaling pathway	3	0.00196	12.2	Pygm, Tsc2, and Prkaca
Lysosome	2	0.0185	9.61	Gaa, Atp6v0a1
Taste transduction	2	0.00499	19.1	Gnas, Prkaca
Progesterone-mediated oocyte maturation	2	0.0157	10.5	Hsp90ab1, Prkaca
Parkinson's disease	2	0.0343	6.89	Ube2l3, Ndufa10
Long-term potentiation	2	0.00809	14.9	Camk2b, Prkaca
Hedgehog signaling pathway	2	0.00421	20.8	Csnk1e, Prkaca
Wnt signaling pathway	3	0.00276	10.8	Csnk1e, Camk2b, and Prkaca
Vascular smooth muscle contraction	2	0.0212	8.94	Gnas, Prkaca
MAPK signaling pathway	3	0.0132	6.11	Mapt, Cacnb1, and Prkaca
Starch and sucrose metabolism	2	0.00284	25.4	Pygm, Gaa
Gene set: upregulated genes
Chemokine signaling pathway	4	1.09E − 4	16.2	Ccl21c, Ccl21a, Ccl9, and Ccl7
Cytokine-cytokine receptor interaction	5	1.43E − 5	16.2	Tnfrsf12a, Ccl21c, Ccl21a, Ccl9, and Ccl7