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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: J Urol. 2011 May 14;186(1):117–124. doi: 10.1016/j.juro.2011.03.027

Figure 4.

Figure 4

Distinct regional gray matter densities reflect different clinical parameters of CP/CPPS. A, whole brain covariate map of voxel-wise gray matter density and pain intensity in patients with CP/CPPS shows positively correlated regions. Right anterior insula was main region identified (ant insula, blue circle) and further analyzed (bar graph and scatterplot). Peak right anterior insula gray matter density shows no difference between patients with CP/CPPS and healthy controls (bar graph), and significant positive correlation between density and pain intensity in patients with CP/CPPS (scatterplot). VAS, visual analog scale. ns, not significant. B, whole brain covariate map of voxel-wise gray matter density and pain duration (in log units) shows regions positively correlated with pain chronicity, identifying mainly anterior cingulate cortex (blue circle). Bar graph shows no difference for peak ACC gray matter density between patients with CP/CPPS and healthy controls. Scatterplot depicts significant positive correlation between ACC density and pain chronicity in patients with CP/CPPS.