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. 2016 Jun 2;7:205. doi: 10.3389/fphys.2016.00205

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Copyright © 2016 Pinto, Mourão, da Silva, Camargo, Marques, Gomes, Fajemiroye, da Silva Reis, Rebelo, Ferreira-Neto, Rosa, Freiria-Oliveira, Castro, Colombari, Colugnati and Pedrino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiovascular, sympathetic, and respiratory responses induced by BB₁ receptors blockade into RVLM. Changes produced by bilateral nanoinjecton of vehicle (150 mM NaCl) and BIM-23127 (3 mM; BB₁ receptor antagonist; 1, 5, and 15 min) into RVLM on mean arterial pressure (MAP; A), renal sympathetic nerve activity (RSNA; B), diaphragm burst amplitude (DIA Burst Amp; C), and respiratory frequency (fR; D) in normotensive and hypertensive rats. ^*different from vehicle; ^†different from normotensive rats. p < 0.05; n = 6.