Table 1.
Body weight (b.w) and basal values of mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and respiratory frequency (fR) of normotensive (NT) and spontaneously hypertensive rats (SHR) that received nanoinjections of bombesin (BBS; 0.3 mM) or BIM-23127 (3 mM) into RVLM.
| Groups | Injection | b.w (g) | MAP (mmHg) | RSNA (a.u.) | fR (cpm) |
|---|---|---|---|---|---|
| NT I | BBS | 294.7 ± 4.9 | 86.3 ± 5.6 | 0.052 ± 0.02 | 95.9 ± 3.1 |
| NT II | BIM-23127 | 287.1 ± 6.7 | 92.4 ± 5.1 | 0.061 ± 0.01 | 96.1 ± 6.5 |
| NT III | BBS-BIM-BBS | 284 ± 4.2 | 108.1 ± 8.9 | 0.123 ± 0.01 | 102.8 ± 11.4 |
| SHR I | BBS | 275.7 ± 3.8 | 127.6 ± 2.1* | 0.107 ± 0.02 | 66.0 ± 1.9* |
| SHR II | BIM-23127 | 288.1 ± 7.1 | 126.6 ± 3.1* | 0.163 ± 0.05 | 69.3 ± 3.4* |
| SHR III | BBS-BIM-BBS | 291.1 ± 5.2 | 127.0 ± 2.9* | 0.110 ± 0.02 | 70.8 ± 5.5* |
Values are expressed as mean ± SEM.
*
different from normotensive groups; p < 0.05. n = 3–7.